Scientists from the Joslin Diabetes Center are currently conducting a study aimed at revealing the physiological factors that contribute to obesity, and found a cell cycle transcription co-regulator (TRIP-Br2) in energy metabolism and fat It plays an important role in storage. This study found that it may lead to new treatments for obesity. The results of the study were published online in the journal Nature Medicine. Transcription co-regulators can control DNA expression by activating or inhibiting gene expression. Scientists at the Joslin Diabetes Center are dedicated to studying the large number of factors that control the storage, mobilization, and utilization of excess energy in fat cells and their regulatory mechanisms. New research shows that TRIP-Br2 regulates metabolic genes related to fat storage and energy metabolism. Scientists tested TRIP-Br2 levels in mice fed a low-fat and high-fat diet and obese mice, and found that the levels of TRIP-Br2 in adipose tissue of high-fat and obese mice were higher. They also found that TRIP-Br2 in visceral fat of obese people was significantly increased. As we all know, the accumulation of fat in the middle of the body is more harmful than other parts of the body. Studies have found that the increase in TRIP-Br2 levels of such obese people is particularly obvious. To clarify the physiological effects of TRIP-Br2 on fat storage and metabolism, scientists conducted an experimental study using genetically engineered mice (called KO mice) that could not generate TRIP-Br2, and these KO mice were fed low-fat or high-fat, respectively diet. The experimental results show that the body weight of KO mice on a high-fat diet rarely changes, similar to that of KO mice fed a low-fat diet. However, due to increased heat production and oxygen consumption, KO mice have increased energy consumption. In addition, high-fat diet KO mice had increased glucose tolerance and insulin sensitivity, and decreased triglycerides. When TRIP-Br2 is inhibited, the expression of hormone-sensitive lipase (HSL) and Beta3 adrenergic (Adrb3) receptors associated with lipolysis is significantly increased in adipose tissue. Conversely, when obesity and a high-fat diet cause TRIP-Br2 to increase, HSL and Adrb3 receptors are inhibited, resulting in reduced energy expenditure and increased fat accumulation. The lead author of the article, Dr. Rohit N. Kulkarni, an associate professor of medicine and the subject leader of the islet cell and regenerative biology department of the Harvard Medical School, said: "TRIP-Br2 is essential for fat accumulation. When an animal lacks TRIP-Br2, It cannot accumulate fat. " In addition to regulating fat storage, TRIP-Br2 also regulates lipolysis, energy output and oxidative metabolism-they complement each other and work together. "This is the first time that a cell cycle co-regulatory factor controls these processes. Unlike previous studies that have reported as transcriptional co-regulatory factors, TRIP-Br2 appears to work through a different mechanism," Dr. Kulkarni said . For obesity and related complications including insulin resistance, TRIP-Br2 is a potential therapeutic target. Scientists at the Joslin Diabetes Center are currently studying ways to "reduce TRIP-Br2 in visceral fat and increase the expression of HSL and Adrb3 receptors. The ability to change these two molecules provides us with a new signal to fight obesity. Access, "Dr. Kulkarni said. In addition, Dr. Kulkarni and colleagues are also investigating the effect of inhibiting TRIP-Br2 and the resulting obesity resistance on cardiovascular disease and metabolic complications. Clean Brush,Kitchen Household Artifact,Household Detachable Toilet Brush,Household Small Cleaning Brush Huayao Master (Puyang) Automation Equipment Co., Ltd. , https://www.huayaolive.com