For the first time, Cai Gang's research group of the University of Science and Technology of China University of Science and Technology cracked the modular structure of the "transcription central controller" - the intermediary, subverting the misunderstanding that has affected the field of transcription research for more than ten years. The related results were published online in the journal Cell Research, and were evaluated by reviewers as "extremely promoting the understanding of the modular structure of intermediaries and laying a solid foundation for elucidating the molecular mechanisms by which intermediaries regulate transcription." It is understood that intermediaries play a key role in transcription and are called "transcription central controllers". It is a huge molecular machine composed of dozens of different proteins, consisting of three stable modules in the head, middle and tail. Cryo-electron microscopy is currently the only way to resolve the three-dimensional structure of a complete interposer, but limited by the complexity of the structure, the reported electron mirror structure resolution is very low, and it is impossible to locate each module. Therefore, the previous understanding of the modular structure of the intermediaries is ambiguous and contradicts the experimental data of a large number of structures and functions, which greatly limits the understanding of the fine structure and molecular mechanism of the intermediaries. The researcher adopted the strategy of “King Ding Jie Niuâ€, and “dismembered†the complete intermediaries into a combination of modules and modules. By carefully comparing the fine three-dimensional structure of the intermediaries and their various functional modules, the modules were clearly divided for the first time. And redefine the modular organizational structure of the intermediary, thus subverting the wrong module division that has affected for more than ten years. This result is of great significance for revealing the molecular mechanism of gene expression and its regulation, and understanding the mechanism of cell proliferation, development and differentiation. Permanent Hair Color Cream,Hair Color Cream,Permanent Hair Dye Color,Ammonia Free Hair Color SOLO GLOW HAIR COSMETICS , https://www.hairdyecolorfactory.com