Introduction of weighing room and related information

First, the weighing room introduction

The weighing chamber, also known as the negative pressure weighing chamber or the center weighing chamber, is a special local purification equipment for pharmaceutical, microbiology research and scientific experiments. It is a professional used in sampling, weighing, analysis and other industries. The special special studio can control the dust and dust in the work area from spreading out of the operation area, ensuring that the operator does not inhale the items being operated. It is a special purification equipment for controlling dust flying. It provides a vertical unidirectional airflow. Part of the clean air circulates in the work area and is partially discharged to the nearby area to create a negative pressure in the work area to prevent cross-contamination and to ensure a high cleanliness environment in the work area.

The weighing chamber is an environmental protection device that provides micro-negative pressure and vertical airflow. Implementation Standards According to the new GMP and appendix requirements of the Good Manufacturing Practice (2010 revision), the weighing room is a special local purification device for pharmaceutical, microbiological research and scientific experiments, which provides a vertical unidirectional airflow. Part of the clean air circulates in the work area and is partially discharged to the nearby area, which creates a negative pressure in the work area to prevent cross-contamination and is used to ensure a high cleanliness environment in the work area.

Second, the weighing room composition

The weighing room is mainly composed of several parts such as chassis, air supply high efficiency filter, exhaust high efficiency filter, variable air volume fan unit, PLC control system and sensing system. The chassis is made of brushed stainless steel SUS304, which is made of sheet metal. It is beautiful and clean, easy to clean and disinfect. The indoor air passes through the primary filter and the medium efficiency filter, and is pressed into the static pressure box by the centrifugal fan. After passing through the high efficiency filter, the air is blown out from the air outlet surface of the airflow diffusing air supply unit, and the clean air flows through the working area at a uniform cross section wind speed. To form a high clean working environment. The operating area of ​​the center weighing chamber is maintained at a negative pressure state, discharging 10% of the circulating air. The air in the center weighing chamber is self-circulating through a three-stage filtration system (high-efficiency filter removes 99.99% of all dust above ≥0.3μm) and is designed to meet the GMP requirements of the pharmaceutical company.

The negative pressure weighing chamber and the center weighing chamber adopt the adjustable air volume fan system and the stainless steel wind speed sensor. By adjusting the working condition of the fan, the average wind speed in the clean working area can be kept within the range of 0.45 m/s. Inside. The airflow manifold of the negative pressure weighing chamber and the central weighing chamber is vertically fed back. The air flows through the work area from top to bottom, and the flying dust generated in the work is pressed to the initial effect, the medium effect and the bag into the bag-out device under the side. The air is pumped by the fan to the high-efficiency filter static pressure box, and part of the air is efficiently passed. The filter is sent back to the indoor working area, and the other part is discharged to the outside of the working area through the exhaust filter, so that a negative pressure is formed in the negative pressure weighing chamber and the negative pressure sampling chamber (central weighing chamber, weighing chamber). The negative pressure weighing chamber and the center weighing chamber are equipped with four differential pressure sensors: indoor and outdoor negative pressure, primary and secondary efficiency resistance, high efficiency air supply resistance, high exhaust gas resistance, air speed sensor, and differential pressure sensor using Siemens PLC controller. Online dynamic control of the weighing room working state, can be stored, printed, displayed, automatically corrected from the set working state, the correction still has a deviation alarm.

Third, the weighing room application range

The weighing chamber is mainly used for the weighing of medicines, and the indoor is negative pressure, which can reduce the pollution of the surrounding environment by the medicines in the dispensing process. Dust, reagent weighing and dispensing can be carried out in the equipment. It can control dust, reagent spillage and uplift, prevent dust and reagents from inhaling harm to human body, avoid cross-contamination of dust and reagents, and protect the environment and indoor personnel. . The weighing operating area is protected by a thousand vertical laminar flow ISO6 (NF, EN, ISO 14644-1).

Fourth, the weighing room structure features and working principle

1, structural characteristics

The equipment is assembled from a working area, a return air box body, a wind box body, an air outlet box body and an outer box body. The control panel is located on the front of the internal working area of ​​the device. The control panel adopts the light touch LED control panel, which can control the fan to start and stop, adjust the fan working condition, and adjust the wind speed required by the working area (after the equipment is installed and used, the special personnel should adjust the working condition. ). There is a differential pressure gauge beside it, and the resistance of the test filter has an exhaust air regulating plate inside the air supply box body, which can adjust the exhaust air volume of the equipment within a reasonable range (after the equipment is installed, it is set by a professional Try, don't adjust it yourself)

2, working principle

The device adopts the vertical unidirectional flow of airflow, and the return air is pre-filtered through the primary effect filter to dispose the large particle dust particles in the airflow, and the pretreated air is passed through the intermediate effect filter. Secondary filtration to fully protect the high efficiency filter. Under the pressure provided by the centrifugal fan, the high efficiency filter is used to achieve the cleanliness requirements. The clean air flow is sent to the air supply box, 90% through the uniform flow air supply stencil to form a uniform vertical air supply airflow, and 10% through the air volume adjustment plate to discharge the equipment. All airflows are treated by high-efficiency filters, so the air is supplied and the exhaust air is free of residual dust, which avoids secondary pollution. Due to the formation of a stable unidirectional flow in the working area, the dust emitted in this area is trapped by the primary and secondary filters with the flow of air under the influence of the unidirectional air flow. The equipment has 10% exhaust air, which forms a negative pressure relative to the external environment, which ensures that the dust in this area will not spread to the outside to protect the external environment.

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